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GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats.

GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy

model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase(SDH)-positive

muscle fibres in both trained and untrained mice.

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